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No it should not be a problem but your host should be able to recursively change permissions on your entire data directory for you if you have permissions issues changing the permissions. They must be 777 permissions.
As far as a blank page thats easy php is timing out so your php is not set correctly to allow larger file uploads if you need assistance please link a php info file and I will guide you on what to alter to assist you. Usually with a blank page altering the memory_limit in php to a higher memory and setting your max_execution_limit to 0 will help.
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